According to Harman's free radical theory of aging, organisms age because cells accumulate free radical damage with the passage of time.

UV and free radicals induce inflammation and damage cell content such as DNA, the extracellular matrix as well as the cell membranes as well as increasing cell proliferation resulting in premature aging


Preventing oxidative damage may delay premature aging


Antioxidants are commonly used in skin care to fight aging. One such antioxidant recently was developed based on colorless carotenoid (a patented technology of IBR Ltd.), also branded as IBR-Phyto(flu)eneTM.

Phytoene is a colorless symmetric molecule containing three conjugated double bonds. Phytoene has typical absorption spectra in the UVB range with maximum at 286 nm and with e1% of 915.

Phytofluene is colorless, with a typical absorption spectra in the UVA range, with maximal absorption at 348 nm and with e1% of 1557.

The colorless carotenoids phytoene and phytofluene (Ph&Pf) are natural carotenoids that lack visible color due to their lower number of conjugated double bonds on the C40 carbon backbone of the molecule. This structure allows them to absorb light in the UVA and UVB range and quench the free radicals formed by UV light - with or without the presence of sunscreens.

Analysis of several fruits and vegetables showed that phytoene and phytofluene are found in majority of fruits and vegetables. In contrast to all other carotenoids, phytoene and phytofluene, the first carotenoid precursors in the biosynthetic pathway of other carotenoids, are colorless and absorb light in the UV range only. It is important to note that dietary phytoene and phytofluene are accumulated in human skin. The accumulation of these colorless carotenoids can potentially protect the skin by several mechanisms: acting as UV absorbers, as antioxidants, as anti inflammatory. The distribution of phytoene and phytofluene in human serum, prostate, and skin suggests that phytoene and phytofluene may be responsible for the carotenoid protective effects observed in beauty and skin applications.

Phytoene and phytofluene were initially discovered as a potent and stable substitutes to pigmented carotenoids to protect the skin via oral and mostly topical application. The colorless carotenoids may be beneficial for health protection and nutritional and beauty applications such as protection against UV and oxidative damage. Several articles summarized their protective activities against UV irradiation and free radicals derived from UV, damage to DNA and collagen, anti-inflammatory and the ability to reduce pigmentation. All of which lead to reduction in pre-mature aging and damaged skin resulting in brighter, younger looking and protected skin

These colorless carotenoids shown good antioxidant capacity against hydroxyl radicals.  These capabilities, among others, enable them to reduce damage to DNA and collagen degradation while reducing inflammation.  Thus, the addition of the phytoene and phytofluene, the COLORLESS CAROTENOIDS, to sun protection formulas could reduce the risk of skin damage, as was previously shown.






IBR-TCLC®TOMATO COLORLESS CAROTENOIDS INCI: Solanum Lycopersicum (Tomato) Fruit Extract

PhytoflORAL®PHYTOENE AND PHYTOFLUENE for Beauty from Within  


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